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Image Search Results
Journal: PLoS ONE
Article Title: IRX-2, a Novel Immunotherapeutic, Enhances Functions of Human Dendritic Cells
doi: 10.1371/journal.pone.0047234
Figure Lengend Snippet: ( A ) DC obtained from HNSCC patients were matured for 48 h either with IRX-2 or the conventional maturation cocktail. While conventionally matured DC (white bars) expressed higher levels of CD80, CD83 and CD86 (*, p<0.05), IRX-2 matured DC (black bars) showed higher expression of CD11c, CD40 and CCR7 (*, p<0.05). The data are mean x-fold of MFI ± SEM for cells obtained from 12 different HNSCC patients. ( B ) Representative histograms showing expression of DC markers after maturation with IRX-2 or the conventional cytokine cocktail in DC generated from monocytes of one HNSCC patient. The shaded peaks represent isotype controls. ( C ) Migration of mDC in vitro : Migration assays were performed as described in Materials & Methods using DC generated from peripheral blood monocytes of HNSCC patients. While iDC showed very little migration in response to CCL21, both conventional- and IRX-2-matured DC migrated significantly better. Results are shown as the mean absolute numbers of migrated cells ± SEM obtained from 5 different HNSCC patients.
Article Snippet:
Techniques: Expressing, Generated, Migration, In Vitro